Endocrine Abstracts

Adrenocortical tumorigenesis has been observed in mice. It is speculated to be gonadotropin dependent. In particular LH receptors appear to be found within such adrenal tumors in high density and elevated LH levels may be related to adrenal tumorigenesis. The aim was to describe the case of a patient who after ovariectomy developed a large malignant adrenal tumor. A patient, female, aged 42 presented with uterine leiomyomas. She was treated by surgical excision of the uterus a...

Tocilizumab is an interleukin-6 receptor antagonist used in the treatment of rheumatoid arthritis (RA). It is known to induce remission and inhibit radiographic progression in RA. Tocilizumab may be administered either intravenously or subcutaneously. Its effect on lipid levels and the cardiovascular risk has not been fully investigated. The aim was to study the effect of tocilizumab administered either iv or sc on disease activity, lipid levels and cardiovascular risk in RA p...

Nonalcoholic fatty liver disease has an increased worldwide prevalence due to obesity and the use of various drugs affecting the liver. The pathogenesis of nonalcoholic fatty liver disease is presently not completely defined. In addition, there is a paucity of agents for its treatment. Choline deficiency has been shown to induce nonalcoholic liver disease. Systemic autoimmune rheumatic diseases require chronic systemic treatment with various agents, which may affect liver func...

Graft vs host disease is a disorder in which the graft, i.e. bone marrow, attacks the host after bone marrow transplantation. It has various manifestations, one being skin and muscle involvement with cutaneous sclerosis and diffuse muscle pain. The aim was to describe the case of a patient with graft vs host disease complicated by insulin resistance and metabolic syndrome, after bone marrow transplantation for the treatment of acute lymphoblastic leukemia.<p class="abstext...

Introduction: Infection from the severe respiratory distress syndrome coronavirus 2 (SARS-CoV-2) virus may present as mild disease or as severe disease with high mortality. Although the majority of patients infected by the virus have a good prognosis, chronic diseases, such as diabetes mellitus (DM), especially in older adults may be a risk factor for a worse outcome. DM is a frequent comorbidity in patients with COVID-19. Aim: The aim of the present wor...

Osteoporosis may be a disease of unknown etiology, or a degenerative disorder in the context of aging. Nowadays, the availability of multiple forms of effective drug treatment for osteoporosis have raised the hypothesis that osteoporosis may be not only a treatable but moreover a curable disease.The aim was to describe the case of a patient with osteoporosis who after treatment with alendronate for 6 years had osteopenia and remains in the state of osteo...

Primary hyperparathyroidism is known to coexist with thyroid cancer and breast cancer. However, primary hyperparathyroidism coexisting with Graves’ disease is extremely rare. The aim was to describe the case of a patient with Graves’ disease causing severe hyperthyroidism who in the course of the disease developed vitamin D deficiency and primary hyperparathyroidism. A patient, female, aged 49 years, presented with severe hyperthyroidism causing tachycardia, palpitat...

Introduction: Neurofibromatosis type 1 or von Recklinghausen disease is a systemic hereditary disease characterized by disorders regarding the skin, neural and skeletal systems. Osteoporosis is one of the skeletal manifestations of neurofibromatosis type 1, being associated with increased fracture risk. Neurofibromatosis type 1 is associated with a propensity for the development of cancer, breast cancer in particular being associated with neurofibromatosis type 1.<p class=...

: Postmenopausal osteoporosis is a common condition affecting many women. Management of postmenopausal osteoporosis involves the administration of vitamin D, calcium and antiresorptive agents. The long-term management of postmenopausal osteoporosis with antiresorptive agents may present some dangers and adverse effects such as bone necrosis or atypical bone fractures.Case report: The aim was to describe the case of a female patient with postmenopausal ...

Vitamin D deficiency has been observed in diabetes mellitus type 2 patients. It has been found to be related to poor glycemic control in diabetes mellitus type 2 patients as well as in patients with gestational diabetes. The administration of vitamin D in diabetes mellitus type 2 patients with vitamin D deficiency has been found to have conflicting results on blood glucose control. The aim was to assess the effect of vitamin D administration in diabetes mellitus type 2 patient...